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Membrane Topology of NAADP-sensitive Two-pore Channels and Their Regulation by N-linked Glycosylation
Two-pore channels (TPCs) localize to the endolysosomal system and have recently emerged as targets for the Ca(2+)-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). However, their membrane topology is unknown. Using fluorescence protease protection assays, we show that huma...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3059026/ https://ncbi.nlm.nih.gov/pubmed/21173144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.189985 |
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