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Membrane Topology of NAADP-sensitive Two-pore Channels and Their Regulation by N-linked Glycosylation

Two-pore channels (TPCs) localize to the endolysosomal system and have recently emerged as targets for the Ca(2+)-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). However, their membrane topology is unknown. Using fluorescence protease protection assays, we show that huma...

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Main Authors: Hooper, Robert, Churamani, Dev, Brailoiu, Eugen, Taylor, Colin W., Patel, Sandip
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059026/
https://ncbi.nlm.nih.gov/pubmed/21173144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.189985
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