In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells

Microtubules (MTs) mediate mitosis, directional signaling, and are therapeutic targets in cancer. Yet in vivo analysis of cancer cell MT behavior within the tumor microenvironment remains challenging. Here we developed an imaging pipeline using plus-end tip tracking and intravital microscopy to quan...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Luthria, Gaurav, Li, Ran, Wang, Stephanie, Prytyskach, Mark, Kohler, Rainer H., Lauffenburger, Douglas A., Mitchison, Timothy J., Weissleder, Ralph, Miller, Miles A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360550/
https://ncbi.nlm.nih.gov/pubmed/32665556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17147-y
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