Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation

[Image: see text] Prodrug strategies that facilitate localized and controlled activity of small-molecule therapeutics can reduce systemic exposure and improve pharmacokinetics, yet limitations in activation chemistry have made it difficult to assign tunable multifunctionality to prodrugs. Here, we p...

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Bibliografski detalji
Izdano u:ACS Nano
Glavni autori: Miller, Miles A., Mikula, Hannes, Luthria, Gaurav, Li, Ran, Kronister, Stefan, Prytyskach, Mark, Kohler, Rainer H., Mitchison, Timothy, Weissleder, Ralph
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2018
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307086/
https://ncbi.nlm.nih.gov/pubmed/30550257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.8b07954
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