Wnt-Induced Stabilization of KDM4C Is Required for Wnt/β-Catenin Target Gene Expression and Glioblastoma Tumorigenesis

Wnt/β-catenin signaling activates the transcription of target genes to regulate stem cells and cancer development. However, the contribution of epigenetic regulation to this process is unknown. Here, we report that Wnt activation stabilizes the epigenetic regulator KDM4C that promotes tumorigenesis...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Chen, Yaohui, Fang, Runping, Yue, Chen, Chang, Guoqiang, Li, Peng, Guo, Qing, Wang, Jing, Zhou, Aidong, Zhang, Sicong, Fuller, Gregory N, Shi, Xiaobing, Huang, Suyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360480/
https://ncbi.nlm.nih.gov/pubmed/31888886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1229
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