Wnt-Induced Stabilization of KDM4C Is Required for Wnt/β-Catenin Target Gene Expression and Glioblastoma Tumorigenesis

Wnt/β-catenin signaling activates the transcription of target genes to regulate stem cells and cancer development. However, the contribution of epigenetic regulation to this process is unknown. Here, we report that Wnt activation stabilizes the epigenetic regulator KDM4C that promotes tumorigenesis...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Cancer Res
Auteurs principaux: Chen, Yaohui, Fang, Runping, Yue, Chen, Chang, Guoqiang, Li, Peng, Guo, Qing, Wang, Jing, Zhou, Aidong, Zhang, Sicong, Fuller, Gregory N, Shi, Xiaobing, Huang, Suyun
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360480/
https://ncbi.nlm.nih.gov/pubmed/31888886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1229
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires