Wnt-Induced Stabilization of KDM4C Is Required for Wnt/β-Catenin Target Gene Expression and Glioblastoma Tumorigenesis

Wnt/β-catenin signaling activates the transcription of target genes to regulate stem cells and cancer development. However, the contribution of epigenetic regulation to this process is unknown. Here, we report that Wnt activation stabilizes the epigenetic regulator KDM4C that promotes tumorigenesis...

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Pubblicato in:Cancer Res
Autori principali: Chen, Yaohui, Fang, Runping, Yue, Chen, Chang, Guoqiang, Li, Peng, Guo, Qing, Wang, Jing, Zhou, Aidong, Zhang, Sicong, Fuller, Gregory N, Shi, Xiaobing, Huang, Suyun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360480/
https://ncbi.nlm.nih.gov/pubmed/31888886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1229
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