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Wnt‐induced deubiquitination FoxM1 ensures nucleus β‐catenin transactivation

A key step of Wnt signaling activation is the recruitment of β‐catenin to the Wnt target‐gene promoter in the nucleus, but its mechanisms are largely unknown. Here, we identified FoxM1 as a novel target of Wnt signaling, which is essential for β‐catenin/TCF4 transactivation. GSK3 phosphorylates FoxM...

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Bibliografiska uppgifter
I publikationen:EMBO J
Huvudupphovsmän: Chen, Yaohui, Li, Yu, Xue, Jianfei, Gong, Aihua, Yu, Guanzhen, Zhou, Aidong, Lin, Kangyu, Zhang, Sicong, Zhang, Nu, Gottardi, Cara J, Huang, Suyun
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801947/
https://ncbi.nlm.nih.gov/pubmed/26912724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201592810
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