Development of a Self-Restricting CRISPR-Cas9 System to Reduce Off-Target Effects

Development of the CRISPR-Cas9 gene-editing system has given rise to a new era of gene editing with wide applications in biology, medicine, agriculture, and other fields. However, the overexpression of Cas9 nuclease causes off-target effects and may trigger an immune response in vivo. Therefore, we...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Wang, Hui, Lu, Hua, Lei, Ying-shou, Gong, Chen-yu, Chen, Zhao, Luan, Ying-qiao, Li, Qiang, Jian, Ying-zhen, Wang, Hao-zheng, Wu, Feng-lin, Tao, Chang-li, Shen, Han, Bo, Hua-ben, Shao, Hong-wei, Zhang, Wen-feng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7358219/
https://ncbi.nlm.nih.gov/pubmed/32695841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.06.012
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