Naturally occurring off-switches for CRISPR-Cas9

CRISPR-Cas9 technology would be enhanced by the ability to inhibit Cas9 function spatially, temporally, or conditionally. Previously, we discovered small proteins encoded by bacteriophages that inhibit the CRISPR-Cas systems of their host bacteria. These “anti-CRISPRs” were specific to type I CRISPR...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Pawluk, April, Amrani, Nadia, Zhang, Yan, Garcia, Bianca, Hidalgo-Reyes, Yurima, Lee, Jooyoung, Edraki, Alireza, Shah, Megha, Sontheimer, Erik J., Maxwell, Karen L., Davidson, Alan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5757841/
https://ncbi.nlm.nih.gov/pubmed/27984730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.11.017
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