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Off-target Effects in CRISPR/Cas9-mediated Genome Engineering
CRISPR/Cas9 is a versatile genome-editing technology that is widely used for studying the functionality of genetic elements, creating genetically modified organisms as well as preclinical research of genetic disorders. However, the high frequency of off-target activity (≥50%)—RGEN (RNA-guided endonu...
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| Publicado no: | Mol Ther Nucleic Acids |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4877446/ https://ncbi.nlm.nih.gov/pubmed/26575098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.37 |
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