Off-target Effects in CRISPR/Cas9-mediated Genome Engineering

CRISPR/Cas9 is a versatile genome-editing technology that is widely used for studying the functionality of genetic elements, creating genetically modified organisms as well as preclinical research of genetic disorders. However, the high frequency of off-target activity (≥50%)—RGEN (RNA-guided endonu...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Mol Ther Nucleic Acids
Главные авторы: Zhang, Xiao-Hui, Tee, Louis Y, Wang, Xiao-Gang, Huang, Qun-Shan, Yang, Shi-Hua
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
Предметы:
Review
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877446/
https://ncbi.nlm.nih.gov/pubmed/26575098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.37
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы