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Off-target Effects in CRISPR/Cas9-mediated Genome Engineering
CRISPR/Cas9 is a versatile genome-editing technology that is widely used for studying the functionality of genetic elements, creating genetically modified organisms as well as preclinical research of genetic disorders. However, the high frequency of off-target activity (≥50%)—RGEN (RNA-guided endonu...
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| 出版年: | Mol Ther Nucleic Acids |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4877446/ https://ncbi.nlm.nih.gov/pubmed/26575098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.37 |
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