Cryo-EM Structure and Molecular Dynamics Analysis of the Fluoroquinolone Resistant Mutant of the AcrB Transporter from Salmonella

Salmonella is an important genus of Gram-negative pathogens, treatment of which has become problematic due to increases in antimicrobial resistance. This is partly attributable to the overexpression of tripartite efflux pumps, particularly the constitutively expressed AcrAB-TolC. Despite its clinica...

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Bibliographic Details
Published in:Microorganisms
Main Authors: Johnson, Rachel M., Fais, Chiara, Parmar, Mayuriben, Cheruvara, Harish, Marshall, Robert L., Hesketh, Sophie J., Feasey, Matthew C., Ruggerone, Paolo, Vargiu, Attilio V., Postis, Vincent L. G., Muench, Stephen P., Bavro, Vassiliy N.
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7355581/
https://ncbi.nlm.nih.gov/pubmed/32585951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/microorganisms8060943
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