MAGGIE: leveraging genetic variation to identify DNA sequence motifs mediating transcription factor binding and function

MOTIVATION: Genetic variation in regulatory elements can alter transcription factor (TF) binding by mutating a TF binding motif, which in turn may affect the activity of the regulatory elements. However, it is unclear which motifs are prone to impact transcriptional regulation if mutated. Current mo...

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Bibliographische Detailangaben
Veröffentlicht in:Bioinformatics
Hauptverfasser: Shen, Zeyang, Hoeksema, Marten A, Ouyang, Zhengyu, Benner, Christopher, Glass, Christopher K
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Comparative and Functional Genomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7355228/
https://ncbi.nlm.nih.gov/pubmed/32657363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btaa476
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