Molecular basis for the distinct functions of redox-active and FeS-transfering glutaredoxins

Despite their very close structural similarity, CxxC/S-type (class I) glutaredoxins (Grxs) act as oxidoreductases, while CGFS-type (class II) Grxs act as FeS cluster transferases. Here we show that the key determinant of Grx function is a distinct loop structure adjacent to the active site. Engineer...

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Publicado no:Nat Commun
Main Authors: Trnka, Daniel, Engelke, Anna D., Gellert, Manuela, Moseler, Anna, Hossain, Md Faruq, Lindenberg, Tobias T., Pedroletti, Luca, Odermatt, Benjamin, de Souza, João V., Bronowska, Agnieszka K., Dick, Tobias P., Mühlenhoff, Uli, Meyer, Andreas J., Berndt, Carsten, Lillig, Christopher Horst
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351949/
https://ncbi.nlm.nih.gov/pubmed/32651396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17323-0
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