Molecular basis for the distinct functions of redox-active and FeS-transfering glutaredoxins

Despite their very close structural similarity, CxxC/S-type (class I) glutaredoxins (Grxs) act as oxidoreductases, while CGFS-type (class II) Grxs act as FeS cluster transferases. Here we show that the key determinant of Grx function is a distinct loop structure adjacent to the active site. Engineer...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Trnka, Daniel, Engelke, Anna D., Gellert, Manuela, Moseler, Anna, Hossain, Md Faruq, Lindenberg, Tobias T., Pedroletti, Luca, Odermatt, Benjamin, de Souza, João V., Bronowska, Agnieszka K., Dick, Tobias P., Mühlenhoff, Uli, Meyer, Andreas J., Berndt, Carsten, Lillig, Christopher Horst
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2020
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351949/
https://ncbi.nlm.nih.gov/pubmed/32651396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17323-0
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы