Molecular basis for the distinct functions of redox-active and FeS-transfering glutaredoxins

Despite their very close structural similarity, CxxC/S-type (class I) glutaredoxins (Grxs) act as oxidoreductases, while CGFS-type (class II) Grxs act as FeS cluster transferases. Here we show that the key determinant of Grx function is a distinct loop structure adjacent to the active site. Engineer...

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Pubblicato in:Nat Commun
Autori principali: Trnka, Daniel, Engelke, Anna D., Gellert, Manuela, Moseler, Anna, Hossain, Md Faruq, Lindenberg, Tobias T., Pedroletti, Luca, Odermatt, Benjamin, de Souza, João V., Bronowska, Agnieszka K., Dick, Tobias P., Mühlenhoff, Uli, Meyer, Andreas J., Berndt, Carsten, Lillig, Christopher Horst
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351949/
https://ncbi.nlm.nih.gov/pubmed/32651396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17323-0
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