Molecular basis for the distinct functions of redox-active and FeS-transfering glutaredoxins

Despite their very close structural similarity, CxxC/S-type (class I) glutaredoxins (Grxs) act as oxidoreductases, while CGFS-type (class II) Grxs act as FeS cluster transferases. Here we show that the key determinant of Grx function is a distinct loop structure adjacent to the active site. Engineer...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Trnka, Daniel, Engelke, Anna D., Gellert, Manuela, Moseler, Anna, Hossain, Md Faruq, Lindenberg, Tobias T., Pedroletti, Luca, Odermatt, Benjamin, de Souza, João V., Bronowska, Agnieszka K., Dick, Tobias P., Mühlenhoff, Uli, Meyer, Andreas J., Berndt, Carsten, Lillig, Christopher Horst
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351949/
https://ncbi.nlm.nih.gov/pubmed/32651396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17323-0
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky