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Structural basis of seamless excision and specific targeting by piggyBac transposase

The piggyBac DNA transposon is used widely in genome engineering applications. Unlike other transposons, its excision site can be precisely repaired without leaving footprints and it integrates specifically at TTAA tetranucleotides. We present cryo-EM structures of piggyBac transpososomes: a synapti...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Chen, Qiujia, Luo, Wentian, Veach, Ruth Ann, Hickman, Alison B., Wilson, Matthew H., Dyda, Fred
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351741/
https://ncbi.nlm.nih.gov/pubmed/32651359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17128-1
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