Chimeric piggyBac transposases for genomic targeting in human cells

Integrating vectors such as viruses and transposons insert transgenes semi-randomly and can potentially disrupt or deregulate genes. For these techniques to be of therapeutic value, a method for controlling the precise location of insertion is required. The piggyBac (PB) transposase is an efficient...

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Autors principals: Owens, Jesse B., Urschitz, Johann, Stoytchev, Ilko, Dang, Nong C., Stoytcheva, Zoia, Belcaid, Mahdi, Maragathavally, Kommineni J., Coates, Craig J., Segal, David J., Moisyadi, Stefan
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
Matèries:
Synthetic Biology and Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413120/
https://ncbi.nlm.nih.gov/pubmed/22492708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks309
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