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Structural basis of seamless excision and specific targeting by piggyBac transposase
The piggyBac DNA transposon is used widely in genome engineering applications. Unlike other transposons, its excision site can be precisely repaired without leaving footprints and it integrates specifically at TTAA tetranucleotides. We present cryo-EM structures of piggyBac transpososomes: a synapti...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7351741/ https://ncbi.nlm.nih.gov/pubmed/32651359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17128-1 |
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