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Structural basis of seamless excision and specific targeting by piggyBac transposase

The piggyBac DNA transposon is used widely in genome engineering applications. Unlike other transposons, its excision site can be precisely repaired without leaving footprints and it integrates specifically at TTAA tetranucleotides. We present cryo-EM structures of piggyBac transpososomes: a synapti...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Chen, Qiujia, Luo, Wentian, Veach, Ruth Ann, Hickman, Alison B., Wilson, Matthew H., Dyda, Fred
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351741/
https://ncbi.nlm.nih.gov/pubmed/32651359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17128-1
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