Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis

BACKGROUND: Genetic mutations in α-actinin-4 (ACTN4)—an important actin crosslinking cytoskeletal protein that provides structural support for kidney podocytes—have been linked to proteinuric glomerulosclerosis in humans. However, the effect of post-translational modifications of ACTN4 on podocyte i...

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Pubblicato in:J Am Soc Nephrol
Autori principali: Feng, Di, Kumar, Mukesh, Muntel, Jan, Gurley, Susan B., Birrane, Gabriel, Stillman, Isaac E., Ding, Lai, Wang, Minxian, Ahmed, Saima, Schlondorff, Johannes, Alper, Seth L., Ferrante, Tom, Marquez, Susan L., Ng, Carlos F., Novak, Richard, Ingber, Donald E., Steen, Hanno, Pollak, Martin R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2020
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351002/
https://ncbi.nlm.nih.gov/pubmed/32540856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019101032
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