Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis

BACKGROUND: Genetic mutations in α-actinin-4 (ACTN4)—an important actin crosslinking cytoskeletal protein that provides structural support for kidney podocytes—have been linked to proteinuric glomerulosclerosis in humans. However, the effect of post-translational modifications of ACTN4 on podocyte i...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Feng, Di, Kumar, Mukesh, Muntel, Jan, Gurley, Susan B., Birrane, Gabriel, Stillman, Isaac E., Ding, Lai, Wang, Minxian, Ahmed, Saima, Schlondorff, Johannes, Alper, Seth L., Ferrante, Tom, Marquez, Susan L., Ng, Carlos F., Novak, Richard, Ingber, Donald E., Steen, Hanno, Pollak, Martin R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2020
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351002/
https://ncbi.nlm.nih.gov/pubmed/32540856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019101032
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