Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis

BACKGROUND: Genetic mutations in α-actinin-4 (ACTN4)—an important actin crosslinking cytoskeletal protein that provides structural support for kidney podocytes—have been linked to proteinuric glomerulosclerosis in humans. However, the effect of post-translational modifications of ACTN4 on podocyte i...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Am Soc Nephrol
Main Authors: Feng, Di, Kumar, Mukesh, Muntel, Jan, Gurley, Susan B., Birrane, Gabriel, Stillman, Isaac E., Ding, Lai, Wang, Minxian, Ahmed, Saima, Schlondorff, Johannes, Alper, Seth L., Ferrante, Tom, Marquez, Susan L., Ng, Carlos F., Novak, Richard, Ingber, Donald E., Steen, Hanno, Pollak, Martin R.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2020
Teme:
Basic Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351002/
https://ncbi.nlm.nih.gov/pubmed/32540856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019101032
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