Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis

BACKGROUND: Genetic mutations in α-actinin-4 (ACTN4)—an important actin crosslinking cytoskeletal protein that provides structural support for kidney podocytes—have been linked to proteinuric glomerulosclerosis in humans. However, the effect of post-translational modifications of ACTN4 on podocyte i...

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Dades bibliogràfiques
Publicat a:J Am Soc Nephrol
Autors principals: Feng, Di, Kumar, Mukesh, Muntel, Jan, Gurley, Susan B., Birrane, Gabriel, Stillman, Isaac E., Ding, Lai, Wang, Minxian, Ahmed, Saima, Schlondorff, Johannes, Alper, Seth L., Ferrante, Tom, Marquez, Susan L., Ng, Carlos F., Novak, Richard, Ingber, Donald E., Steen, Hanno, Pollak, Martin R.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2020
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351002/
https://ncbi.nlm.nih.gov/pubmed/32540856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019101032
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