Quantifying DNA damage induced by ionizing radiation and hyperthermia using single DNA molecule imaging

Ionizing radiation (IR) is a common mode of cancer therapy, where DNA damage is the major reason of cell death. Here, we use an assay based on fluorescence imaging of single damaged DNA molecules isolated from radiated lymphocytes, to quantify IR induced DNA damage. The assay uses a cocktail of DNA-...

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Publicado en:Transl Oncol
Main Authors: Singh, Vandana, Johansson, Pegah, Torchinsky, Dmitry, Lin, Yii-Lih, Öz, Robin, Ebenstein, Yuval, Hammarsten, Ola, Westerlund, Fredrik
Formato: Artigo
Idioma:Inglês
Publicado: Neoplasia Press 2020
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Original article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7350159/
https://ncbi.nlm.nih.gov/pubmed/32652469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100822
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