Quantifying DNA damage induced by ionizing radiation and hyperthermia using single DNA molecule imaging

Ionizing radiation (IR) is a common mode of cancer therapy, where DNA damage is the major reason of cell death. Here, we use an assay based on fluorescence imaging of single damaged DNA molecules isolated from radiated lymphocytes, to quantify IR induced DNA damage. The assay uses a cocktail of DNA-...

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Bibliographic Details
Published in:Transl Oncol
Main Authors: Singh, Vandana, Johansson, Pegah, Torchinsky, Dmitry, Lin, Yii-Lih, Öz, Robin, Ebenstein, Yuval, Hammarsten, Ola, Westerlund, Fredrik
Format: Artigo
Language:Inglês
Published: Neoplasia Press 2020
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Original article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7350159/
https://ncbi.nlm.nih.gov/pubmed/32652469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100822
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