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Quantifying DNA damage induced by ionizing radiation and hyperthermia using single DNA molecule imaging

Ionizing radiation (IR) is a common mode of cancer therapy, where DNA damage is the major reason of cell death. Here, we use an assay based on fluorescence imaging of single damaged DNA molecules isolated from radiated lymphocytes, to quantify IR induced DNA damage. The assay uses a cocktail of DNA-...

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Bibliografische gegevens
Gepubliceerd in:Transl Oncol
Hoofdauteurs: Singh, Vandana, Johansson, Pegah, Torchinsky, Dmitry, Lin, Yii-Lih, Öz, Robin, Ebenstein, Yuval, Hammarsten, Ola, Westerlund, Fredrik
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Neoplasia Press 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7350159/
https://ncbi.nlm.nih.gov/pubmed/32652469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100822
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