Targeting Nuclear NOTCH2 by Gliotoxin Recovers a Tumor-Suppressor NOTCH3 Activity in CLL

NOTCH signaling represents a promising therapeutic target in chronic lymphocytic leukemia (CLL). We compared the anti-neoplastic effects of the nuclear NOTCH2 inhibitor gliotoxin and the pan-NOTCH γ-secretase inhibitor RO4929097 in primary CLL cells with special emphasis on the individual roles of t...

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Publicat a:Cells
Autors principals: Hubmann, Rainer, Schnabl, Susanne, Araghi, Mohammad, Schmidl, Christian, Rendeiro, André F., Hilgarth, Martin, Demirtas, Dita, Ali, Farghaly, Staber, Philipp B., Valent, Peter, Zielinski, Christoph, Jäger, Ulrich, Shehata, Medhat
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7348714/
https://ncbi.nlm.nih.gov/pubmed/32570839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9061484
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