Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model

Deregulation of NOTCH2 signaling is implicated in a wide variety of human neoplasias. The current concept of targeting NOTCH is based on using gamma secretase inhibitors (GSI) to regulate the release of the active NOTCH intracellular domain. However, the clinical outcome of GSI remains unsatisfactor...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Hubmann, Rainer, Sieghart, Wolfgang, Schnabl, Susanne, Araghi, Mohammad, Hilgarth, Martin, Reiter, Marlies, Demirtas, Dita, Valent, Peter, Zielinski, Christoph, Jäger, Ulrich, Shehata, Medhat
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500618/
https://ncbi.nlm.nih.gov/pubmed/28736522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00319
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