Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model

Deregulation of NOTCH2 signaling is implicated in a wide variety of human neoplasias. The current concept of targeting NOTCH is based on using gamma secretase inhibitors (GSI) to regulate the release of the active NOTCH intracellular domain. However, the clinical outcome of GSI remains unsatisfactor...

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Detaylı Bibliyografya
Yayımlandı:Front Pharmacol
Asıl Yazarlar: Hubmann, Rainer, Sieghart, Wolfgang, Schnabl, Susanne, Araghi, Mohammad, Hilgarth, Martin, Reiter, Marlies, Demirtas, Dita, Valent, Peter, Zielinski, Christoph, Jäger, Ulrich, Shehata, Medhat
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2017
Konular:
Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500618/
https://ncbi.nlm.nih.gov/pubmed/28736522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00319
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