UGT2B17 modifies drug response in chronic lymphocytic leukaemia

BACKGROUND: High UGT2B17 is associated with poor prognosis in untreated chronic lymphocytic leukaemia (CLL) patients and its expression is induced in non-responders to fludarabine-containing regimens. We examined whether UGT2B17, the predominant lymphoid glucuronosyltransferase, affects leukaemic dr...

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Pubblicato in:Br J Cancer
Autori principali: Allain, Eric P., Rouleau, Michèle, Vanura, Katrina, Tremblay, Sophie, Vaillancourt, Joanie, Bat, Vincent, Caron, Patrick, Villeneuve, Lyne, Labriet, Adrien, Turcotte, Véronique, Le, Trang, Shehata, Medhat, Schnabl, Susanne, Demirtas, Dita, Hubmann, Rainer, Joly-Beauparlant, Charles, Droit, Arnaud, Jäger, Ulrich, Staber, Philipp B., Lévesque, Eric, Guillemette, Chantal
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7374097/
https://ncbi.nlm.nih.gov/pubmed/32418995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0887-6
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