Inactivation of Prostaglandin E(2) as a Mechanism for UGT2B17-Mediated Adverse Effects in Chronic Lymphocytic Leukemia

High expression of the metabolic enzyme UDP-glucuronosyltransferase UGT2B17 in chronic lymphocytic leukemia (CLL) cells was associated with poor prognosis in two independent studies. However, the underlying mechanism remains unknown. We hypothesized that UGT2B17 impacts intracellular levels of hormo...

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Detalles Bibliográficos
Publicado en:Front Oncol
Main Authors: Allain, Eric P., Rouleau, Michèle, Le, Trang, Vanura, Katrina, Villeneuve, Lyne, Caron, Patrick, Turcotte, Véronique, Lévesque, Eric, Guillemette, Chantal
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6621974/
https://ncbi.nlm.nih.gov/pubmed/31334126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00606
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