Inactivation of Prostaglandin E(2) as a Mechanism for UGT2B17-Mediated Adverse Effects in Chronic Lymphocytic Leukemia

High expression of the metabolic enzyme UDP-glucuronosyltransferase UGT2B17 in chronic lymphocytic leukemia (CLL) cells was associated with poor prognosis in two independent studies. However, the underlying mechanism remains unknown. We hypothesized that UGT2B17 impacts intracellular levels of hormo...

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Bibliografske podrobnosti
izdano v:Front Oncol
Main Authors: Allain, Eric P., Rouleau, Michèle, Le, Trang, Vanura, Katrina, Villeneuve, Lyne, Caron, Patrick, Turcotte, Véronique, Lévesque, Eric, Guillemette, Chantal
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Oncology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6621974/
https://ncbi.nlm.nih.gov/pubmed/31334126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00606
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