The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus

The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH). The pyrimidines uracil, thymine and cytosine are the building blocks of DNA and RNA; thus, inhibition of their synthesis i...

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Bibliographic Details
Published in:J Fungi (Basel)
Main Authors: du Pré, Saskia, Birch, Mike, Law, Derek, Beckmann, Nicola, Sibley, Graham E. M., Bromley, Michael J., Read, Nick D., Oliver, Jason D.
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7345704/
https://ncbi.nlm.nih.gov/pubmed/32290206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jof6020047
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