The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus

The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH). The pyrimidines uracil, thymine and cytosine are the building blocks of DNA and RNA; thus, inhibition of their synthesis i...

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Vydáno v:J Fungi (Basel)
Hlavní autoři: du Pré, Saskia, Birch, Mike, Law, Derek, Beckmann, Nicola, Sibley, Graham E. M., Bromley, Michael J., Read, Nick D., Oliver, Jason D.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7345704/
https://ncbi.nlm.nih.gov/pubmed/32290206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jof6020047
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