Effect of the Novel Antifungal Drug F901318 (Olorofim) on Growth and Viability of Aspergillus fumigatus

F901318 (olorofim) is a novel antifungal drug that is highly active against Aspergillus species. Belonging to a new class of antifungals called the orotomides, F901318 targets dihydroorotate dehydrogenase (DHODH) in the de novo pyrimidine biosynthesis pathway. In this study, the antifungal effects o...

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Foilsithe in:Antimicrob Agents Chemother
Main Authors: du Pré, Saskia, Beckmann, Nicola, Almeida, Mariana Cruz, Sibley, Graham E. M., Law, Derek, Brand, Alexandra C., Birch, Mike, Read, Nick D., Oliver, Jason D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2018
Ábhair:
Susceptibility
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105813/
https://ncbi.nlm.nih.gov/pubmed/29891595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00231-18
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