F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase

There is an important medical need for new antifungal agents with novel mechanisms of action to treat the increasing number of patients with life-threatening systemic fungal disease and to overcome the growing problem of resistance to current therapies. F901318, the leading representative of a novel...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Oliver, Jason D., Sibley, Graham E. M., Beckmann, Nicola, Dobb, Katharine S., Slater, Martin J., McEntee, Laura, du Pré, Saskia, Livermore, Joanne, Bromley, Michael J., Wiederhold, Nathan P., Hope, William W., Kennedy, Anthony J., Law, Derek, Birch, Mike
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111691/
https://ncbi.nlm.nih.gov/pubmed/27791100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608304113
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