F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase

There is an important medical need for new antifungal agents with novel mechanisms of action to treat the increasing number of patients with life-threatening systemic fungal disease and to overcome the growing problem of resistance to current therapies. F901318, the leading representative of a novel...

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Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Oliver, Jason D., Sibley, Graham E. M., Beckmann, Nicola, Dobb, Katharine S., Slater, Martin J., McEntee, Laura, du Pré, Saskia, Livermore, Joanne, Bromley, Michael J., Wiederhold, Nathan P., Hope, William W., Kennedy, Anthony J., Law, Derek, Birch, Mike
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2016
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111691/
https://ncbi.nlm.nih.gov/pubmed/27791100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608304113
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