F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase

There is an important medical need for new antifungal agents with novel mechanisms of action to treat the increasing number of patients with life-threatening systemic fungal disease and to overcome the growing problem of resistance to current therapies. F901318, the leading representative of a novel...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Oliver, Jason D., Sibley, Graham E. M., Beckmann, Nicola, Dobb, Katharine S., Slater, Martin J., McEntee, Laura, du Pré, Saskia, Livermore, Joanne, Bromley, Michael J., Wiederhold, Nathan P., Hope, William W., Kennedy, Anthony J., Law, Derek, Birch, Mike
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111691/
https://ncbi.nlm.nih.gov/pubmed/27791100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608304113
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