R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation

G-quadruplex (G4) is a noncanonical secondary structure of DNA or RNA which can enhance or repress gene expression, yet the underlying molecular mechanism remains uncertain. Here we show that when positioned downstream of transcription start site, the orientation of potential G4 forming sequence (PQ...

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Udgivet i:Nat Commun
Main Authors: Lee, Chun-Ying, McNerney, Christina, Ma, Kevin, Zhao, Walter, Wang, Ashley, Myong, Sua
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341879/
https://ncbi.nlm.nih.gov/pubmed/32636376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17176-7
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