The aptamer BT200 effectively inhibits von Willebrand factor (VWF) dependent platelet function after stimulated VWF release by desmopressin or endotoxin

Von Willebrand factor (VWF) plays a major role in arterial thrombosis. Antiplatelet drugs induce only a moderate relative risk reduction after atherothrombosis, and their inhibitory effects are compromised under high shear rates when VWF levels are increased. Therefore, we investigated the ex vivo e...

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Publicat a:Sci Rep
Autors principals: Kovacevic, Katarina D., Buchtele, Nina, Schoergenhofer, Christian, Derhaschnig, Ulla, Gelbenegger, Georg, Brostjan, Christine, Zhu, Shuhao, Gilbert, James C., Jilma, Bernd
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341806/
https://ncbi.nlm.nih.gov/pubmed/32636459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68125-9
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