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A physics-based energy function allows the computational redesign of a PDZ domain

Computational protein design (CPD) can address the inverse folding problem, exploring a large space of sequences and selecting ones predicted to fold. CPD was used previously to redesign several proteins, employing a knowledge-based energy function for both the folded and unfolded states. We show th...

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Publicat a:Sci Rep
Autors principals: Opuu, Vaitea, Sun, Young Joo, Hou, Titus, Panel, Nicolas, Fuentes, Ernesto J., Simonson, Thomas
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341745/
https://ncbi.nlm.nih.gov/pubmed/32636412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67972-w
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