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Adaptive landscape flattening allows the design of both enzyme: Substrate binding and catalytic power
Designed enzymes are of fundamental and technological interest. Experimental directed evolution still has significant limitations, and computational approaches are a complementary route. A designed enzyme should satisfy multiple criteria: stability, substrate binding, transition state binding. Such...
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| Publicado no: | PLoS Comput Biol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7041857/ https://ncbi.nlm.nih.gov/pubmed/31917825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007600 |
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