Adaptive landscape flattening allows the design of both enzyme: Substrate binding and catalytic power

Designed enzymes are of fundamental and technological interest. Experimental directed evolution still has significant limitations, and computational approaches are a complementary route. A designed enzyme should satisfy multiple criteria: stability, substrate binding, transition state binding. Such...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS Comput Biol
Main Authors: Opuu, Vaitea, Nigro, Giuliano, Gaillard, Thomas, Schmitt, Emmanuelle, Mechulam, Yves, Simonson, Thomas
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041857/
https://ncbi.nlm.nih.gov/pubmed/31917825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007600
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