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A physics-based energy function allows the computational redesign of a PDZ domain
Computational protein design (CPD) can address the inverse folding problem, exploring a large space of sequences and selecting ones predicted to fold. CPD was used previously to redesign several proteins, employing a knowledge-based energy function for both the folded and unfolded states. We show th...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7341745/ https://ncbi.nlm.nih.gov/pubmed/32636412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67972-w |
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