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Substrate Anchoring and the Catalytic Power of Enzymes

Evidence from published nuclear magnetic resonance studies of enzyme-substrate and enzyme-inhibitor systems systems shows that substrates are confined at the active site of the enzyme, have a relatively long residence time, and tumble in solution as an enzyme-substrate complex. The consequences of t...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Author: Reuben, Jacques
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1971
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC388989/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/5276762/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.68.3.563
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