Synthesis of 5-(Fluoroalkyl)isoxazole Building Blocks by Regioselective Reactions of Functionalized Halogenoximes

A comprehensive study on the synthesis of 5-fluoroalkyl-substituted isoxazoles starting from functionalized halogenoximes is reported. One-pot metal-free [3+2] cycloaddition of CF(3)-substituted alkenes and halogenoximes bearing ester, bromo, chloromethyl, and protected amino groups was developed fo...

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Veröffentlicht in:J Org Chem
Hauptverfasser: Chalyk, Bohdan A., Hrebeniuk, Kateryna V., Fil, Yulia V., Gavrilenko, Konstantin S., Rozhenko, Alexander B., Vashchenko, Bohdan V., Borysov, Oleksandr V., Biitseva, Angelina V., Lebed, Pavlo S., Bakanovych, Iulia, Moroz, Yurii S., Grygorenko, Oleksandr O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341682/
https://ncbi.nlm.nih.gov/pubmed/31626546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b02264
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