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Generating Multibillion Chemical Space of Readily Accessible Screening Compounds

An approach to the generation of ultra-large chemical libraries of readily accessible (“REAL”) compounds is described. The strategy is based on the use of two- or three-step three-component reaction sequences and available starting materials with pre-validated chemical reactivity. After the prelimin...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Grygorenko, Oleksandr O., Radchenko, Dmytro S., Dziuba, Igor, Chuprina, Alexander, Gubina, Kateryna E., Moroz, Yurii S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593547/
https://ncbi.nlm.nih.gov/pubmed/33145486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101681
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