Regioselective Synthesis of Functionalized 3- or 5-Fluoroalkyl Isoxazoles and Pyrazoles from Fluoroalkyl Ynones and Binucleophiles

A facile synthetic route towards either 3- or 5-fluoroalkyl-substituted isoxazoles or pyrazoles containing an additional functionalization site was developed and applied on a multigram scale. The elaborated approach extends the scope of fluoroalkyl substituents for introduction into the heterocyclic...

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Pubblicato in:J Org Chem
Autori principali: Chalyk, Bohdan A., Khutorianskyi, Andrii, Lysenko, Andrii, Fil, Yulia, Kuchkovska, Yuliya O., Gavrilenko, Konstantin S., Bakanovych, Iulia, Moroz, Yurii S., Gorlova, Alina O., Grygorenko, Oleksandr O.33
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7310498/
https://ncbi.nlm.nih.gov/pubmed/31661620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b02258
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