Synthesis of 5-(Fluoroalkyl)isoxazole Building Blocks by Regioselective Reactions of Functionalized Halogenoximes

A comprehensive study on the synthesis of 5-fluoroalkyl-substituted isoxazoles starting from functionalized halogenoximes is reported. One-pot metal-free [3+2] cycloaddition of CF(3)-substituted alkenes and halogenoximes bearing ester, bromo, chloromethyl, and protected amino groups was developed fo...

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Bibliografiska uppgifter
I publikationen:J Org Chem
Huvudupphovsmän: Chalyk, Bohdan A., Hrebeniuk, Kateryna V., Fil, Yulia V., Gavrilenko, Konstantin S., Rozhenko, Alexander B., Vashchenko, Bohdan V., Borysov, Oleksandr V., Biitseva, Angelina V., Lebed, Pavlo S., Bakanovych, Iulia, Moroz, Yurii S., Grygorenko, Oleksandr O.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341682/
https://ncbi.nlm.nih.gov/pubmed/31626546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b02264
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