Lung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT Ligand KITLG/SCF and Gene-By-Air-Pollution Interaction

Baseline lung function, quantified as forced expiratory volume in the first second of exhalation (FEV(1)), is a standard diagnostic criterion used by clinicians to identify and classify lung diseases. Using whole-genome sequencing data from the National Heart, Lung, and Blood Institute Trans-Omics f...

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Vydáno v:Genetics
Hlavní autoři: Mak, Angel C. Y., Sajuthi, Satria, Joo, Jaehyun, Xiao, Shujie, Sleiman, Patrick M., White, Marquitta J., Lee, Eunice Y., Saef, Benjamin, Hu, Donglei, Gui, Hongsheng, Keys, Kevin L., Lurmann, Fred, Jain, Deepti, Abecasis, Gonçalo, Kang, Hyun Min, Nickerson, Deborah A., Germer, Soren, Zody, Michael C., Winterkorn, Lara, Reeves, Catherine, Huntsman, Scott, Eng, Celeste, Salazar, Sandra, Oh, Sam S., Gilliland, Frank D., Chen, Zhanghua, Kumar, Rajesh, Martínez, Fernando D., Wu, Ann Chen, Ziv, Elad, Hakonarson, Hakon, Himes, Blanca E., Williams, L. Keoki, Seibold, Max A., Burchard, Esteban G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337089/
https://ncbi.nlm.nih.gov/pubmed/32327564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.120.303231
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