Functional genomics of CDHR3 confirms its role in HRV-C infection and childhood asthma exacerbations

BACKGROUND: Research in transformed, immortalized cell lines indicates the cadherin-related family member 3 (CDHR3) protein serves as a receptor for human rhinovirus C (HRV-C). Similar experiments indicate the CDHR3 coding variant, rs6967330, increases CDHR3 protein surface expression. OBJECTIVE: To...

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Udgivet i:J Allergy Clin Immunol
Main Authors: Everman, Jamie L., Sajuthi, Satria, Saef, Benjamin, Rios, Cydney, Stoner, Ari M., Numata, Mari, Hu, Donglei, Eng, Celeste, Oh, Sam, Rodriguez-Santana, Jose, Vladar, Eszter K., Voelker, Dennis R., Burchard, Esteban G., Seibold, Max A.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766426/
https://ncbi.nlm.nih.gov/pubmed/30930175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2019.01.052
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