Lung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT Ligand KITLG/SCF and Gene-By-Air-Pollution Interaction

Baseline lung function, quantified as forced expiratory volume in the first second of exhalation (FEV(1)), is a standard diagnostic criterion used by clinicians to identify and classify lung diseases. Using whole-genome sequencing data from the National Heart, Lung, and Blood Institute Trans-Omics f...

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Gepubliceerd in:Genetics
Hoofdauteurs: Mak, Angel C. Y., Sajuthi, Satria, Joo, Jaehyun, Xiao, Shujie, Sleiman, Patrick M., White, Marquitta J., Lee, Eunice Y., Saef, Benjamin, Hu, Donglei, Gui, Hongsheng, Keys, Kevin L., Lurmann, Fred, Jain, Deepti, Abecasis, Gonçalo, Kang, Hyun Min, Nickerson, Deborah A., Germer, Soren, Zody, Michael C., Winterkorn, Lara, Reeves, Catherine, Huntsman, Scott, Eng, Celeste, Salazar, Sandra, Oh, Sam S., Gilliland, Frank D., Chen, Zhanghua, Kumar, Rajesh, Martínez, Fernando D., Wu, Ann Chen, Ziv, Elad, Hakonarson, Hakon, Himes, Blanca E., Williams, L. Keoki, Seibold, Max A., Burchard, Esteban G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Genetics Society of America 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337089/
https://ncbi.nlm.nih.gov/pubmed/32327564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.120.303231
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